The Binding of Isaac: Rebirth Easy Unlocks – Tainted Cain (Cillith) Strategy

The Binding of Isaac: Rebirth Easy Unlocks – Tainted Cain (Cillith) Strategy 1 -
The Binding of Isaac: Rebirth Easy Unlocks – Tainted Cain (Cillith) Strategy 1 -
Tired of wanting to become back your money?
This guide will help you beat trash Issac using the most broken character!




This strategy will allow you to become Lilith as Tainted Cain, adopting her love for familiars and using said familiars to form an army of unstoppable anguish, hence Cillith (Lilith + Cain + Kill = Cillith)



Early Game

Crafting 3 Freezer Babies, 1 Tractor Beam, and a whole lot of pain!


Crafting more familiars, building your army to slay whatever enters your path!


Do what you need to do basically, a useless section of encouragement!

Switching to Other Characters

Utilising The Clicker, also telling you how not to break the game and get stuck as Tainted Forgotten

Useful Synergies

Some great trinkets and items to aid your army further!


Thanks for reading!

Early Game

Step 1: Start The Run
Okay, first off you need to start your run as Tainted Cain.

Step 2: Conjoined
Okay, this is the hardest part. You are going to need 3 familiars to get the Conjoined Transformation.

The easiest and strongest familiar to craft is the Freezer Baby, costing only:
1 red heart, 5 pennies, 2 bombs

Step 3: Tractor Beam
Once you are Conjoined, craft yourself a Tractor Beam:
6 pennies, 2 keys

Step 4: BFFs! (OPTIONAL)
This is entirely optional but highly recommended, craft BFFs!:
1 soul heart, 2 pennies, 5 bombs OR 2 red hearts, 1 penny, 1 nickel, 2 keys, 2 bombs

Step 5: Birthright (OPTIONAL)
Another optional but highly recommended item is Birthright, as it increases the amount of drops from item pedestals, i.e. more material to craft with!
2 red hearts, 2 soul hearts, 3 pennies, 1 bomb OR 3 pennies, 4 bombs, 1 pill


That’s your DPS set up for now! You can steamroll early-game bosses efficiently with the familiars and triple shot you just gained, alongside your supportive frozen friends!


As you go further into mid-game (i.e. Depths), you’re going to want to build your army further, crafting as mean cheap familiars as possible (or more expensive one’s, depending on your luck).

This is where the guide is flexible, you can either build up the army or focus on building up your tear rate, damage or range!


Cheap Familiars
These familiars are the cheapest, easiest to obtain!

Little Steven1 red heart, 1 soul heart, 1 penny, 1 key, 4 bombs

Brother Bobby1 soul heart, 4 pennies, 1 key, 2 bombs

Robo-Baby4 red hearts, 2 pennies, 2 keys

Rainbow Baby7 pennies, 1 nickel


Useful Familiars
These familiars are going to help carry your run, however they are not the cheapest so if you have crafted Birthright, you may be lucky enough to get these!

Incubus1 red heart, 4 soul hearts, 1 black heart, 1 key, 1 rune/soul

Guardian Angel3 red hearts, 1 eternal heart, 1 penny, 2 keys, 1 bomb

Lil’ Brimstone4 soul hearts, 2 pennies, 1 nickel, 1 bomb

Rotten Baby1 soul heart, 1 penny, 3 nickels, 3 bombs


Okay, so you reached end-game, you’re probably vibing in Cathedral / Sheol / Corpse, or you’re moving your way back up to the beast. This is where you can either do the dirty Bait & Switch or go beat the bosses as Tainted Cain.


Pretty much keep going how you are, focus on your build, or just bulk up and let the army of familiars do the work! This is entirely your call now!

Switching to Other Characters

The Bait & Switch
Okay so you are going for unlocks for other characters, you are going to want to craft some things before you go for The Clicker.

Step 1: The Battery
You are firstly going to need The Battery, the reason being is you need two, full charges on The Clicker so you don’t get stuck as Tainted Forgotten.

The Battery is cheap so don’t stress:
3 red hearts, 1 soul heart, 4 pennies OR 4 pennies, 1 nickel, 1 key, 2 bombs

Step 2: Battery Pack (OPTIONAL)
Okay, now you have 2 charges, it’s time to get some batteries spawning, you can do this by crafting the Battery Pack:
6 red hearts, 2 pennies OR 4 red hearts, 3 pennies, 2 keys

Step 3: The Clicker
Here’s how you switch to another character, although you will lose 1 item per transformation, so maybe craft a bunch of Breakfastor other trash items so you can keep the good stuff!

The Clickeris crafted cheaply and easily, and using the batteries you can get to your desired character easily!

The Clicker:
3 red hearts, 1 penny, 2 keys, 1 bomb, 1 pill OR 2 red hearts, 2 pennies, 2 nickel;s, 1 key, 1 bomb


It’s useful to note that using the clicker can actually be really helpful, for example Tainted Lazarus will not switch to his Dead form, meaning you do not have to deal with that BS!

All in all, EZ win!

Useful Synergies

Here’s a few useful pick-ups for your journey!

Baby Bender Trinket – Familiars get homing shots

Friendship Neckless Trinket – Familiars circle you

Box of Friends – Duplicates all familiars for the room (CANNOT USE WITH CLICKER)
2 red hearts, 1 soul heart, 1 penny, 1 key, 2 bombs, 1 card

Extension Cord Trinket – Electricity connects all familiars

Forgotten Lullaby Trinket – Buffs all familiar tear rate


Thank you for reading!

This is my first ever guide, I may update with extra (disgusting) ideas or add some of your suggestions (with credit of course!)

Comment what other synergies, tips or tricks you have and I hope this strategy serves you well!

By Clarky01

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